Innovative and creative engagement with social theories is essential if global health researchers and practitioners are going to make transformative change toward health equity. Intersectionality is a versatile tool, which can be used to orient our focus toward the social systems of power that lie at the heart of health inequity. This chapter provides the reader with an introductory overview of intersectionality, its origins, and core tenants, before exploring how global health researchers and practitioners can engage with the theory to deepen conceptualizations of health issues, enhance tools for capturing and understanding experiences of health inequity, and strengthen our approaches to action as we work toward equity. The chapter provides a brief and exploratory example from the first author’s work and proposes some provocations to support readers’ engagement with intersectionality in their global health research and practice.