Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review

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Ferreira, Elaine Barros
Vasques, Christiane Inocencio
Gadia, Rafael
Chan, Raymond Javan
Silva Guerra, Eliete Neves
Mezzomo, Luis Andre
Canto, Graziela De Luca
Diniz dos Reis, Paula Elaine
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2017
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Abstract

Purpose: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis. Methods: Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis. Results: Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention. Conclusions: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

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Supportive Care in Cancer

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25

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3

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© 2017 Springer Berlin/Heidelberg. This is an electronic version of an article published in Supportive Care in Cancer, 2017, 25 (3), pp. 1001-1011. Supportive Care in Cancer is available online at: http://link.springer.com/ with the open URL of your article.

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Biomedical and clinical sciences

Psychology

Science & Technology

Life Sciences & Biomedicine

Oncology

Health Care Sciences & Services

Rehabilitation

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Ferreira, EB; Vasques, CI; Gadia, R; Chan, RJ; Silva Guerra, EN; Mezzomo, LA; Canto, GDL; Diniz dos Reis, PE, Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review, Supportive Care in Cancer, 2017, 25 (3), pp. 1001-1011

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