Background: Both head-mounted display (HMD) and augmented reality (AR) are examples of emergent and disruptive technologies that have had little exposure in pharmacy. The developed HMD-AR warfarin counselling guide allowed pharmacists to examine this technology in a familiar context. Aims: To determine acceptance among pharmacists for the HMD-AR warfarin counselling guide, as a form of emergent and disruptive technology. Methods: Forty Australian community pharmacists were recruited for a cohort study. The study was completed in a pre- and post-test manner, where pharmacists were allowed to explore the HMD-AR warfarin counselling guide. The pre-test included questions related to demographic variables. The post-test used Technology Assessment Model (TAM) based Likert scale questions on a 1–5 (strongly agree to strongly disagree) scale. Questions unrelated to TAM were also included in the pre- and post-test and compared using a Wilcoxon signed-rank test. These engaged participants on perceived usefulness of the HMD-AR warfarin counselling guide and their willingness to use technology. Qualitative feedback to open ended questions in the post-test was also sought. Results: Technology Assessment Model constructs (perceived ease-of-use, perceived usefulness, and behavioural intention) indicated a positive reception overall. Pre- and post-test questions regarding perceived usefulness of the HMD-AR warfarin counselling guide and willingness to use technology declined after using the HMD-AR warfarin counselling guide. Conclusion: Participant expectations although still positive, declined after using the HMD-AR warfarin counselling guide. Further study is needed for technological advances, design optimisation and to assess patient acceptance to ensure the system is fit for purpose for pharmacy practice.