New Triterpene Glucosides from the Roots of Rosa laevigata Michx
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Yang, Xin-Zhou
Miao, Jian-Hua
Tang, Chun-Ping
Ke, Chang-Qiang
Zhang, Ji-Bao
Ma, Xiao-Jun
Ye, Yang
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Abstract
Two new ursane-type triterpene glucosides, 2a,3a,24-trihydroxyurs-12,18-dien-28-oic acid ߭D-glucopyranosyl ester (1) and 2a,3a,23-trihydroxyurs-12,19(29)-dien-28-oic acid ߭D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2a,3߬19a-trihydroxyurs-12-en-28-oic acid ߭Dglucopyranosyl ester (3), 2a,3a,19a-trihydroxyurs-12-en-28-oic acid ߭D-glucopyranosyl ester (4) and 2a,3߬19a,23-tetrahydroxyurs-12-en-28-oic acid ߭D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.
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Molecules
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13
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9
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© 2008 by the authors.licensee Molecular Diversity Preservation International, Basel, Switzerland. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
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Medicinal and Biomolecular Chemistry
Organic Chemistry
Theoretical and Computational Chemistry