The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C
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Davis, Rohan A
Longden, James
Avery, Vicky M
Healy, Peter C
Longden, James
Avery, Vicky M
Healy, Peter C
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2008
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Abstract
Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.
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Bioorganic & Medicinal Chemistry Letters
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18
Issue
9
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Medicinal and biomolecular chemistry
Organic chemistry
Pharmacology and pharmaceutical sciences