The immediate and long-term prognosis for children who display early-onset antisocial behaviour and who are at-risk of disengagement from school is often extremely poor across multiple indices of adjustment, including a significantly increased risk of violence and criminality as adults. Implementing effective programs to redirect the trajectory of antisocial behaviour toward better outcomes for these children is therefore an important priority. The school setting is one of the most important socialization contexts of childhood. It is a place where antisocial behaviour often plays out and where prevention and intervention efforts are often focused. Given the important role of the school in understanding childhood antisocial behaviour, this chapter presents an overview of the contemporary literature on the nature, scope, impact and etiology of childhood antisocial behaviour, with an emphasis on the school context. Efforts undertaken in schools to prevent and/or redirect the trajectory of these children are reviewed.