Activating Platinum Anticancer Complexes with Visible Light
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Berners-Price, Susan J
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2011
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Abstract
The next generation: Classical PtII anticancer compounds contain cis diam(m)ine ligands and are activated by ligand-substitution reactions. PtIV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent.
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Angewandte Chemie International Edition
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50
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4
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Chemical sciences
Bioinorganic chemistry