Due to the large volume of research, therapists often turn to systematic reviews for treatment directions. We expect that these comprehensive syntheses of the literature will provide unambiguous recommendations for the implementation of a particular intervention. However, the conclusions of systematic reviews often leave us feeling unsatisfied because of the absence of clear recommendations due to the paucity of high quality evidence. The aim of this editorial is to provide some guidance for therapists and researchers when faced with a systematic review with inconclusive recommendations. We will use our recent Cochrane systematic review1 as an example.