Aims The aim of this systematic review was to critique research examining the use of nurse-led clinics for head and neck cancers. Method This review was conducted using the Pickering systematic literature review framework. Searching during November 2021, research published between 2011–2021 from the databases MEDLINE, Scopus, PsychINFO, Cochrane and CINAHL was appraised using the Mixed Methods Appraisal Tool (MMAT), descriptive quantitative analysis and thematic analysis. Results A total of 134 articles were recovered, with 13 studies included for analysis. Of these, seven were cohort studies, four were observations-based and five were randomised control trials. Furthermore, 12 of these studies highlighted the role of an outpatient clinicbased nurse practice, and four were based on the generalised role of an advanced practice nurse. Of all 13 studies, only one was based in Australia, with the majority based in either Europe (7) or the USA (8). Conclusion Nurse-led clinics for head and neck cancer follow ups show promising results to improve patients’ quality of life. All 13 studies showed an increase in patient-reported quality of life. Further research may be required to study the financial and resource availability for the utilisation of nurse-led clinics in the future. Impact This study addressed a gap in knowledge of the success and distribution of nurse-led clinics in the field of head and neck cancers. Overall, there is a strong outcome of feasibility and quality patient outcomes for nurse-led clinics. However, there are low sample sizes in the articles found. This may have future impacts on policy and resource funding for further development of nurse-led services; however, further research will be required.