To the editor, We read with interest, the recent study by Corny et al, in which the authors evaluated the changes of intravenous (IV) to oral (PO) conversion practice in a hospital following sequential interventions during a 5‐year period.1 The interventions were mainly focused on IV to PO conversion of acetaminophen and proton‐pump inhibitors (PPIs), and the conversion practice was evaluated assuming the abovementioned medications as “tracers.” The authors concluded that both medications could be considered as tracers of IV/PO switching practices in the hospital, with respect to the observed correlation between IV/PO ratios for acetaminophen and PPIs and ratios for all drugs. We found the topic of the study and its results important; however, there are a few challenges that we thought need more elaboration, specifically about the robustness of the study's methodologies, and the interpretation of its results