Complications of Central Venous Access Devices: A Systematic Review

Loading...
Thumbnail Image
File version

Accepted Manuscript (AM)

Author(s)
Ullman, Amanda J
Marsh, Nicole
Mihala, Gabor
Cooke, Marie
Rickard, Claire M
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2015
Size
File type(s)
Location
License
Abstract

CONTEXT: The failure and complications of central venous access devices (CVADs) result in interrupted medical treatment, morbidity, and mortality for the patient. The resulting insertion of a new CVAD further contributes to risk and consumes extra resources.

OBJECTIVE: To systematically review existing evidence of the incidence of CVAD failure and complications across CVAD types within pediatrics.

DATA SOURCES: Central Register of Controlled Trials, PubMed, and Cumulative Index to Nursing and Allied Health databases were systematically searched up to January 2015.

STUDY SELECTION: Included studies were of cohort design and examined the incidence of CVAD failure and complications across CVAD type in pediatrics within the last 10 years. CVAD failure was defined as CVAD loss of function before the completion of necessary treatment, and complications were defined as CVAD-associated bloodstream infection, CVAD local infection, dislodgement, occlusion, thrombosis, and breakage.

DATA EXTRACTION: Data were independently extracted and critiqued for quality by 2 authors.

RESULTS: Seventy-four cohort studies met the inclusion criteria, with mixed quality of reporting and methods. Overall, 25% of CVADs failed before completion of therapy (95% confidence interval [CI] 20.9%–29.2%) at a rate of 1.97 per 1000 catheter days (95% CI 1.71–2.23). The failure per CVAD device was highest proportionally in hemodialysis catheters (46.4% [95% CI 29.6%–63.6%]) and per 1000 catheter days in umbilical catheters (28.6 per 1000 catheter days [95% CI 17.4–39.8]). Totally implanted devices had the lowest rate of failure per 1000 catheter days (0.15 [95% CI 0.09–0.20]).

LIMITATIONS: The inclusion of nonrandomized and noncomparator studies may have affected the robustness of the research.

CONCLUSIONS: CVAD failure and complications in pediatrics are a significant burden on the health care system internationally.

Journal Title

Pediatrics

Conference Title
Book Title
Edition
Volume

136

Issue

5

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2015 American Academy of Pediatrics. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

Item Access Status
Note
Access the data
Related item(s)
Subject

Biomedical and clinical sciences

Nursing not elsewhere classified

Psychology

Persistent link to this record
Citation
Collections