Numerical Investigation of Analytical Models of Drug Flux Through Microporated Skin
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Rzhevskiy, Alexey S
Anissimov, Yuri G
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Abstract
In this study, drug flux through microporated skin was modeled using detailed numerical solution of the diffusion equation. The results of the modeling were compared to previously published simplified and easy to use analytical equations. Limitations and accuracy of these equations were investigated. Appropriate modifications of the equations were identified to expand them to wider practical applications when pore shape is not circular. Numerical simulations have shown a good accuracy of the new simple equations when these are used within their limits of application.
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JOURNAL OF PHARMACEUTICAL SCIENCES
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108
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1
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© 2019 Wiley Periodicals, Inc. and the American Pharmacists Association. This is the peer reviewed version of the following article: Numerical Investigation of Analytical Models of Drug Flux Through Microporated Skin, Journal of Pharmaceutical Sciences, Vol.108(1):358-363, 2019, which has been published in final form at 10.1016/j.xphs.2018.11.009. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
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Pharmacology and pharmaceutical sciences