Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Loading...
Thumbnail Image
File version
Author(s)
Mackenzie, Jason
Tajouri, Lotfi
Szvetko, Attila
Weth, Verena
Moreau, Julie
Greer, Judith M.
Csurhes, Peter A.
Pender, Michael P.
Griffiths, Lyn
Primary Supervisor
Other Supervisors
Editor(s)
Date
2009
Size

453488 bytes

File type(s)

application/pdf

Location
License
Abstract

Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population. Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR StuI polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence. Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR StuI polymorphism. Conclusion: The results indicate that the LIF 3' UTR StuI polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility.

Journal Title

Journal of the Neurological Sciences

Conference Title
Book Title
Edition
Volume

280

Issue

1

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2009 Elsevier B.V.. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

Item Access Status
Note
Access the data
Related item(s)
Subject

Neurogenetics

Clinical Sciences

Neurosciences

Psychology

Persistent link to this record
Citation
Collections