Lanthanide complexes are definitely bioavailable and have a huge number of implementations in medical analysis and in diagnosis and treatment. Due to their chemical and magnetic properties their use in cancer treatment and therapy increases. Luminescent compounds used as light-emitting materials for biosensors, molecular imaging has gotten profound interest attention in biomedical probe. Gadolinium(III) continues to be the dominant starting material for contrast agent design used in MRI response as a function of a specific biomarker. Contrast agents of lanthanides in MRI show a capacity of effective instrument for tumor diagnosis. Lu (3), Eu (3) based complexes operates in chemotherapy act as therapeutic agent. Dysprosium based drug used in treatment of Rheumatoid arthritis. Gd (3), Sm (3), Nd (3) complexes focuses on detailed image of organs, which helps in detecting diseases in body. Lanthanides, which based on physical and spectral, have wide range of uses including fluorescent probes in biological experiments. This review paper goal is to highlight research on lanthanide compounds with biological and biomedical uses.