The Asia-Pacific region encompasses a vast geographical expanse, characterised by diverse landscapes, climates, cultures, religions, and economies. It is home to the world's two most populous countries, India and China, as well as the Pacific Island countries, which comprise a significant area hosting many of the most isolated and smallest nations on Earth, such as Nauru and the Marshall Islands. Against this backdrop of complexity, the Asia-Pacific region remains a cornerstone of global growth, with Asia projected to contribute to 60 per cent of global GDP growth in 2024. This resilience is rooted in the region's remarkable economic progress over the past five decades, which has lifted hundreds of millions of people out of poverty and positioned several economies at the forefront of technological advancement in areas such as green energy, new energy vehicles, green finance, digital economy, agriculture and food. The Asia-Pacific region has a unique opportunity to become the world’s leader in sustainable development. However, the region faces pressing challenges that undermine its sustainable development potential. Foremost, these include climate change, democratic resilience, inclusive growth, shifting geopolitics, and tightening monetary conditions. The Griffith Asia-Pacific Strategic Outlook (GAPSO) serves as a crucial platform for comprehending the multifaceted challenges and identifying opportunities within the region, addressing both local and global Sustainable Development Goal (SDG) priorities. To this end, the Griffith Asia Institute has collaborated closely with regional partners to identify and analyse megatrends and pathways for navigating the complexities of the Asia- Pacific region, with the overarching aim of unlocking the region's potential to be the global leader in sustainable development. We have identified six major themes – three regional and three sectoral themes that serve as cornerstone for fostering sustainable development leadership in Asia Pacific: green transition, inclusive growth and labor market as sectoral themes, and China, Pacific, Southeast Asia as regional themes. While each theme necessitates specific forms of analysis and measures to drive sustainable development, we have identified four core recommended actions to accelerate Asia-Pacific leadership in sustainable development.