The purpose of the chapter is to explore the association between resilience and well-being, based on evidence from the “Asia-Pacific Resilience Project.” The main research findings derived from the study were (1) low resilience scores predispose individuals to mental health risks and (2) an intervention program using a holistic school approach to promote resilience factors such as self-esteem, self-efficacy, and school connectedness significantly promotes student well-being and prevents mental health problems.