Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology

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Berridge, Michael V
Crasso, Carole
Neuzil, Jiri
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2018
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Abstract

Horizontal gene transfer is known to occur in bacteria and archaea whereas higher organisms including mammals undergo vertical transfer. Our recent results demonstrate horizontal transfer of mitochondrial DNA (mtDNA) from normal host cells to tumor cells lacking mitochondrial DNA (mtDNA). This mtDNA migration results in recovery of respiration, restored tumor initiation, and metastasis.

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Molecular & Cellular Oncology
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Science & Technology
Life Sciences & Biomedicine
Oncology
intercellular DNA transfer
mitochondrial DNA deletion
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Berridge, MV; Crasso, C; Neuzil, J, Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology, Molecular & Cellular Oncology, 2018, 5 (5)
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