Mismatched unrelated donor allogeneic stem cell transplant for high risk haematological malignancy: A single centre experience
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Curley, Cameron
Butler, Jason
Mclean, Angela
Tey, Siok
Hill, Geoffrey R
Morton, Anthony
Misra, Ashish
Subramoniapillai, Elango
Durrant, Simon
Kennedy, Glen A
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Abstract
Human leukocyte antigen (HLA) matched allogeneic stem cell transplant (SCT) is an established curative treatment for various haematologic malignancies1. However, a fully matched HLA-donor may still not be identified in a significant proportion of patients. Those who do not have an available HLA-matched donor can still potentially undertake transplantation utilizing an alternative donor source, including mismatched unrelated donors (MMUD), umbilical cord blood (UCB) or haploidentical donors2. Although MMUD SCT is associated with increased risk of both graft versus host disease (GVHD) and non-relapse mortality (NRM), MMUD have still historically been utilized as alternative donor sources due to ease of donor availability3.
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Blood Cancer Journal
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7
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12
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© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Cardiovascular medicine and haematology
Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Oncology
Hematology
VERSUS-HOST-DISEASE
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Mediwake, H; Curley, C; Butler, J; Mclean, A; Tey, S; Hill, GR; Morton, A; Misra, A; Subramoniapillai, E; Durrant, S; Kennedy, GA, Mismatched unrelated donor allogeneic stem cell transplant for high risk haematological malignancy: A single centre experience, Blood Cancer Journal, 2017, 7 (12)