Efficient energy transfer management in catalytic processes is crucial for overcoming activation energy barriers while minimizing costs and CO2 emissions. We exploit here a concept of CuO particle design with multiple gas-stabilizing sites, engineered to function as cavitation nuclei and catalysts. This concept facilitates the selective and efficient acoustic energy transfer directly to the catalyst surface, avoiding the undesired dissipation of acoustic energy into the bulk solution while demonstrating superior cavitation properties at lower acoustic pressure amplitudes. Utilizing a chemical thermometric approach, we demonstrate that the local temperature on the surface of our CuO particles during cavitation bubble implosions can create an effective equivalent temperature of about 360 °C. This temperature effect facilitates the efficient catalysis of oxidative reactions using an organic pollutant probe molecule. Density functional theory (DFT) calculations were used to assess the decomposition of H2O2 and of pollutant probe molecule on CuO (111). Our work represents a significant advance in sonocatalytic systems, promising efficient energy use in catalytic reactions.