Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra
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Holland, Darren C
Robertson, Luke P
Avery, Vicky M
Carroll, Anthony R
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Abstract
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra. Based on the combination of MS and NMR analyses and comparison of experimental and TDDFT calculated ECD spectra, the absolute structure of 1 was determined. Compound 1 displayed moderate activity against drug sensitive (3D7) and drug resistant (Dd2) strains of the parasite, Plasmodium falciparum, responsible for malaria.
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Organic Letters
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Chemical sciences
Biological sciences
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Prebble, DW; Holland, DC; Robertson, LP; Avery, VM; Carroll, AR, Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra, Organic Letters, 2020