Probing RNA structures and functions by solvent accessibility: an overview from experimental and computational perspectives
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Litfin, Thomas
Singh, Jaswinder
Paliwal, Kuldip
Zhou, Yaoqi
Zhan, Jian
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Abstract
Characterizing RNA structures and functions have mostly been focused on 2D, secondary and 3D, tertiary structures. Recent advances in experimental and computational techniques for probing or predicting RNA solvent accessibility make this 1D representation of tertiary structures an increasingly attractive feature to explore. Here, we provide a survey of these recent developments, which indicate the emergence of solvent accessibility as a simple 1D property, adding to secondary and tertiary structures for investigating complex structure–function relations of RNAs.
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Briefings in Bioinformatics
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23
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3
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© The Author(s) 2022. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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Biochemistry and cell biology
Bioinformatics and computational biology
Genetics
Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Mathematical & Computational Biology
Biochemistry & Molecular Biology
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Solayman, M; Litfin, T; Singh, J; Paliwal, K; Zhou, Y; Zhan, J, Probing RNA structures and functions by solvent accessibility: an overview from experimental and computational perspectives, Briefings in Bioinformatics, 2022, 23 (3)