The role of sex hormones in skeletal muscle adaptation is a subject of ongoing debate. Public perception often associates higher levels of testosterone with increased muscle size, centring the discussion around men. Less consideration has been given to female sex hormones, oestrogen and progesterone, and their influence on skeletal muscle adaptation. Fluctuations in oestrogen and progesterone across the menstrual cycle (MC) is a hallmark of female reproductive physiology, with increasing attention in the scientific and social media communities. It is often assumed that these sex hormones create distinct anabolic and catabolic environments across the MC, potentially affecting responses to resistance exercise. Such assumptions have arisen from anecdotal reporting, popular opinion, physiological theory, and some scientific evidence. In their article published in The Journal of Physiology, Colenso-Semple et al. (2024) dismantle this narrative with precision and elegance. Their findings clearly demonstrate that fluctuations in sex hormones across the MC do not compromise the capacity of women to respond effectively to an appropriate resistance exercise stimulus. The results of the study by Colenso-Semple et al. (2024) prompt a critical question: does the evidence justify ‘MC-phase-based’ resistance exercise training?