In this study, a series of flume tests was systematically conducted to study the pore-water pressures around a monopile under wave and current loading, as well as the hydrodynamic response. Unlike in previous studies, the combined irregular wave and current action were studied, and a partially embedded monopile was considered. Moreover, the influence of wave spectra on the pore-water pressures was studied. The following results were obtained. (1) The irregular wave (current)-induced hydrodynamic response and seabed response around the monopile are stronger than those induced by the representative regular wave (current) loading. (2) A larger irregular wave energy can more often cause a larger pore-water pressure. The influence of irregular wave parameters on the pore-water pressures is mainly concentrated in the upper seabed, and the influence range is enhanced for the existence of current. (3) The current greatly influences the pore-water pressures in the upper and middle layers of the seabed; however, in the lower seabed below the monopile, it has a weaker but more complicated effect on the pore-water pressures. (4) Wave spectra have remarkable effects on the pore-water pressures, and the influence range deepens for the action of current on the wave field.