(1:9 in volume ratio) to simulate synthetic flue gas. CO2 desorption from the amine solution was evaluated using MD at 80 °C. Interaction between amines and the membrane polymeric matrix could alter the membrane surface hydrophobicity; however, under all experimental conditions it was still sufficiently hydrophobic for MD operation. Amine loss during MD operation for CO2 desorption was insignificant. FO was used to provide make-up water and cooling to the regenerated amine solution after CO2 desorption by MD. The results showed stable FO water flux when wastewater effluent was used as the source for make-up water. Repetitive CO2 loading and desorption experiments showed 87.0% and 88.1% CO2 re-absorption efficiency for MEA and sodium glycinate in the second cycle, respectively. Further investigation of this hybrid system is suggested to advance the CO2 desorption by MD process and water production by FO process.