Assessment of the seabed behavior around the marine structure can be a critical process in designing its foundation because of numerous structure failures due to seabed instability. Most of previous studies were either based on the assumption of soil isotropy or only considered regular wave, even though the anisotropic soil behavior and irregular wave impact might have great influence as reported in the literature. In this study, the random wave-induced soil responses in a cross-anisotropic seabed around a harbor entrance are investigated. Results reveals that multi-directional random wave causes greater agitation within the harbor basin comparing to the regular wave. The effect of cross-anisotropic soil behavior on the seabed response is significant and the conventional models for the isotropic seabed overestimates the maximum liquefaction depth.