Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1

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Author(s)
Paterson, I
Chen, DYK
Coster, MJ
Acena, JL
Bach, J
Gibson, KR
Keown, LE
Oballa, RM
Trieselmann, T
Wallace, DJ
Hodgson, AP
Norcross, RD
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2001
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Abstract

An enantioselective total synthesis of spongistatin 1, a.k.a. (+)-altohyrtin A, was achieved via a multistep synthetic sequence which included Wittig olefination, aldol condensation, and macrolactonization.

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Angewandte Chemie, International Edition

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40

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21

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Chemical sciences

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