Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions

Loading...
Thumbnail Image
File version
Version of Record (VoR)
Author(s)
Karam, O
Demaret, P
Duhamel, A
Shefler, A
Spinella, PC
Stanworth, SJ
Tucci, M
Leteurtre, S
Butt, W
Delzoppo, C
Bain, K
Erickson, S
Smalley, N
Long, D
et al.
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2016
Size
File type(s)
Location
License
http://creativecommons.org/licenses/by/4.0/)
Abstract

Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.

Journal Title
Annals of Intensive Care
Conference Title
Book Title
Edition
Volume
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
© 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Clinical sciences
Health services and systems
Public health
Persistent link to this record
Citation
Karam, O; Demaret, P; Duhamel, A; Shefler, A; Spinella, PC; Stanworth, SJ; Tucci, M; Leteurtre, S; for the PlasmaTV investigators, ; Butt, W; Delzoppo, C; Bain, K; Erickson, S; Smalley, N; Long, D; et al., Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions, Annals of Intensive Care, 2016, 6 (1), pp.98
Collections