Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates

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Author(s)
Fujita, Yoshio
Abdel-Aal, Abu-Baker M.
Wimmer, Norbert
Batzloff, Michael R.
Good, Michael F.
Toth, Istvan
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2008
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Abstract

Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2k) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.

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Bioorganic & medicinal chemistry.

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16

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19

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Infectious Agents

Medicinal and Biomolecular Chemistry

Organic Chemistry

Pharmacology and Pharmaceutical Sciences

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