The present study investigates CO2-monoethanolamine (MEA) absorption reaction in a novel honeycomb fractal reactor under the laminar flow, with particular reference to the conventional serpentine tubular reactor. The results show the CO2 removal efficiency and absorption rate increase with the increasing liquid flow rate, as well as the increasing MEA when the other conditions remain unchanged. In general, the CO2 removal efficiency and absorption rate in honeycomb fractal reactor are higher than those in serpentine tubular reactor. The honeycomb-shaped configuration provides reaction space with larger surface-to-volume ratio. The fluid from the upper level channel split at the bifurcation when flowing towards the next level of hexagonal unit, leading to a declined reactant velocity in the latter branches and hence increasing the residence time. Besides, in the honeycomb fractal reactor, the flow pattern is maintained as slug flow in which the contact time and area are intensified, leading to the strengthened interface mass transfer. The maximum CO2 removal efficiency of 168% was obtained in honeycomb fractal reactor.