A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C–H insertion

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Lepage, Romain J
White, Jonathan M
Coster, Mark J
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2017
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Abstract

Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C–H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).

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Chemical Communications

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53

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30

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Chemical sciences

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