Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats

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Ahmed, Romana
Tanvir, EM
Hossen, Md Sakib
Afroz, Rizwana
Ahmmed, Istiyak
Rumpa, Nur-E-Noushin
Paul, Sudip
Gan, Siew Hua
Sulaiman, Siti Amrah
Khalil, Md Ibrahim
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2017
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https://creativecommons.org/licenses/by/4.0/
Abstract

Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values. Herein, we report the antioxidant properties and cardioprotective properties of MP in isoproterenol- (ISO-) inducedmyocardial infarction in rats.MaleWistar rats ( = 32) were pretreated orallywith an ethanol extract ofMP (100mg/kg/day) for 30 consecutive days. Subcutaneous injection of ISO(85mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes and cardiac troponin I levels and altered serum lipid profiles. In addition significantly increased lipid peroxides and decreased activities of cellular antioxidant defense enzymeswere observed in the myocardium. However, pretreatment of ischemic rats with MP ameliorated the biochemical parameters, indicating the protective effect ofMP against ISO-induced ischemia in rats. Histopathological findings obtained for the myocardium further confirmed the biochemical findings. It is concluded that MP exhibits cardioprotective activity against ISO-induced oxidative stress through its direct cytotoxic radical-scavenging activities. It is also plausible that MP contributed to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.

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Evidence-Based Complementary and Alternative Medicine
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© 2017 Romana Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Traditional, complementary and integrative medicine
Science & Technology
Life Sciences & Biomedicine
Integrative & Complementary Medicine
INDUCED MYOCARDIAL-INFARCTION
CARDIAC MARKER ENZYMES
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Ahmed, R; Tanvir, EM; Hossen, MS; Afroz, R; Ahmmed, I; Rumpa, N-E-N; Paul, S; Gan, SH; Sulaiman, SA; Khalil, MI, Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats, Evidence-Based Complementary and Alternative Medicine, 2017, 2017, pp. 5370545
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