Dysinosins B-D, Inhibitors of Factor VIIa and Thrombin from the Australian Sponge Lamellodysidea chlorea

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Carroll, AR
Buchanan, MS
Edser, A
Hyde, E
Simpson, M
Quinn, RJ
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2004
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Abstract

Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.

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Journal of Natural Products

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67

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© 2004 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. TPlease use the hypertext link above to access the journal's website or contact the author for more information.

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Chemical sciences

Biological sciences

Biomedical and clinical sciences

History, heritage and archaeology

Traditional, complementary and integrative medicine

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