0–1 problems are often difficult to solve. Although special purpose algorithms (exact as well as heuristic) exist for solving particular problem classes or problem instances, there are few general purpose algorithms for solving practical-sized instances of 0–1 problems. This paper deals with a general purpose heuristic algorithm for 0–1 problems. In this paper, we compare two methods based on simulated annealing for solving general 0–1 integer programming problems. The two methods differ in the scheme used for neighbourhood transitions in the simulated annealing framework. We compare the performance of the two methods on the set partitioning problem.