Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy

Loading...
Thumbnail Image
File version

Version of Record (VoR)

Author(s)
Tomasetti, Marco
Gaetani, Simona
Monaco, Federica
Neuzil, Jiri
Santarelli, Lory
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2019
Size
File type(s)
Location
Abstract

Asbestos exposure leads to epigenetic and epigenomic modifications that, in association with ROS-induced DNA damage, contribute to cancer onset. Few miRNAs epigenetically regulated in MM have been described in literature; miR-126, however, is one of them, and its expression is regulated by epigenetic mechanisms. Asbestos exposure induces early changes in the miRNAs, which are reversibly expressed as protective species, and their inability to reverse reflects the inability of the cells to restore the physiological miRNA levels despite the cessation of carcinogen exposure. Changes in miRNA expression, which results from genetic/epigenetic changes during tumor formation and evolution, can be detected in fluids and used as cancer biomarkers. This article has reviewed the epigenetic mechanisms involved in miRNA expression in MM, focusing on their role as biomarkers of early diagnosis and therapeutic effects.

Journal Title

Frontiers in Oncology

Conference Title
Book Title
Edition
Volume

9

Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2019 Tomasetti, Gaetani, Monaco, Neuzil and Santarelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Item Access Status
Note
Access the data
Related item(s)
Subject

Oncology and carcinogenesis

Science & Technology

Life Sciences & Biomedicine

Oncology

malignant mesothelioma

epi-miRNAs

Persistent link to this record
Citation

Tomasetti, M; Gaetani, S; Monaco, F; Neuzil, J; Santarelli, L, Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy, Frontiers in Oncology, 2019, 9, pp. 1293: 1-1293: 14

Collections