Background: As cancer mortality rates improve in Asia, there is an increasing need to improve the transition to post-treatment survivorship care. However, culturally appropriate standardized survivorship programs are lacking in this region. This study aimed to evaluate the effectiveness of a culturally adapted psychoeducation program (PE) compared with usual care (UC) to reduce distress and symptoms in Asian breast cancer survivors who have completed adjuvant chemotherapy. Methods: This was a randomized, controlled trial in 72 Asian early-stage breast cancer survivors who were randomized into either the PE (n = 34) or the UC (n = 38) arms. Participants in the PE arm underwent a weekly multidisciplinary psychoeducation program, delivered in a group format over 3 weeks, based on current recommendations from the United States Institute of Medicine, coupled with cultural adaptation. Both arms were assessed at baseline and 2 months post-intervention using the Rotterdam Symptom Checklist and EORTC-QLQ-C30. Effect sizes were calculated using Cohen’s d. Results: The mean age ± SD of all participants was 53.0 ± 8.9 years, with majority being Chinese (84.7%) and Malay (6.9%). At baseline, clinical characteristics and outcome measures were well balanced in both arms. Comparing to UC, there was a significant lower levels of physical symptom distress (d= 0.76, p = 0.01) and fatigue (d= 0.49, p = 0.04). There was also a trend towards less appetite loss (d= 0.46, p = 0.06), less constipation (d= 0.45, p = 0.06) and activity level improvement (d= 0.37, p = 0.14) in the PE arm comparing to the UC arm. Conclusions: A culturally adapted, multidisciplinary psychoeducation program was effective to reduce physical distress and symptoms in Asian breast cancer survivors.