Perfluorooctanoic acid (PFOA, C7F15COOH) has raised global concerns because of its ubiquitous occurrence and resistance to most conventional water treatment techniques. In this work, we first used metal-organic framework (MOF) derived In2O3nanospheres (In2O3NS) and rods for photocatalytic degradation of PFOA under UV light irradiation. XRD was used to confirm the successful preparation of MOF-derived In2O3. SEM images show that In2O3NS and rods were obtained by the calcination of different indium (iii)-benzenedicarboxylate (In-BDC) MOFs. In2O3NS and rods demonstrated enhanced performances for photodegradation of PFOA compared with the commercial In2O3. The results show that PFOA was completely decomposed in 3 h, and its shorter-chain products were further mineralized in 6 h in the presence of In2O3NS under 254 nm UV light irradiation. MOF-derived In2O3is super-hydrophilic with a contact angle of ∼20° and possesses larger specific surface area, which facilitate the adsorption and tight coordination of PFOA with In2O3. Moreover, EIS Nyquist spectra show that the as-prepared In2O3NS and rods have higher efficiency in charge separation and migration compared with the commercial In2O3. All these properties contribute to the destruction of PFOA.