Over a decade of global water research has provided clear evidence on the global dimension of the water challenge and the role of humans as a chief force shaping the global water cycle. Mounting evidence suggests no reversals in major trends and an expectation of intensified and pandemic water problems. Research in the past has emphasized the identification of problems more than the identification of solutions. A clear shift in emphasis towards solutions-oriented approaches is required. The next decade of research should be directed towards motivating a transition from knowledge-to-concrete action, and to find solutions through the co-production of knowledge involving scientists and stakeholders. This paper summarizes a blueprint for a Sustainable Water Future initiative, arguing for the necessity of a strong water programme in global change research. We provide specific suggestions on forming a strategic partnership of scientists, public stakeholders, decision-makers and the private sector to implement a reality-based, multi-perspective, and multi-scale knowledge-to-action water agenda.