Genetic blueprint of the zoonotic pathogen Toxocara canis

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Zhu, Xing-Quan
Korhonen, Pasi K
Cai, Huimin
Young, Neil D
Nejsum, Peter
von Samson-Himmelstjerna, Georg
Boag, Peter R
Tan, Patrick
Li, Qiye
Min, Jiumeng
Yang, Yulan
Wang, Xiuhua
Fang, Xiaodong
Hall, Ross S
Hofmann, Andreas
Sternberg, Paul W
Jex, Aaron R
Gasser, Robin B
Griffith University Author(s)
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2015
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Abstract

Toxocara canis is a zoonotic parasite of major socioeconomic importance worldwide. In humans, this nematode causes disease (toxocariasis) mainly in the under-privileged communities in developed and developing countries. Although relatively well studied from clinical and epidemiological perspectives, to date, there has been no global investigation of the molecular biology of this parasite. Here we use next-generation sequencing to produce a draft genome and transcriptome of T. canis to support future biological and biotechnological investigations. This genome is 317?Mb in size, has a repeat content of 13.5% and encodes at least 18,596 protein-coding genes. We study transcription in a larval, as well as adult female and male stages, characterize the parasite's gene-silencing machinery, explore molecules involved in development or host-parasite interactions and predict intervention targets. The draft genome of T. canis should provide a useful resource for future molecular studies of this and other, related parasites.

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Nature Communications

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6

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© The Author(s) 2014. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Medical parasitology

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