Molecular Characterization of Virulent Newcastle Disease Virus Isolates from Chickens during the 1998 NDV Outbreak in Kazakhstan
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Berezin, Vladiimir
Prilipov, Alexey
Usachev, Eugeniy
Liyapina, Olga
Levandovskya, Svetlana
Korotetskiy, Ivana
Tolmacheva, Valentina
Makhmudova, Nailya
Khudyakova, Svetlana
Tustikbaeva, Gulnur
Zaitseva, Irina
Omirtaeva, Elmira
Ermakova, Olga
Daulbaeva, Klara
Asanova, Saule
Kydyrmanov, Aydyn
Sayatov, Marat
King, Daniel
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Abstract
Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses described previously. For genotyping, fusion (F) gene phylogenetic analysis (nucleotide number 47-421) was performed using sequences of Kazakhstanian isolates as compared to sequences of selected NDV strains from GenBank. Phylogenetic analysis showed that all newly characterized strains belonged to the genetic group designated as VIIb. All strains possessed a virulent fusion cleavage site (RRQRR/F) belonging to velogenic or mesogenic pathotypes with intracerebral pathogenicity indexes (ICPI) varying from 1.05 to 1.87.
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Virus Genes
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31
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1
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Medical Microbiology not elsewhere classified
Microbiology not elsewhere classified
Biological Sciences
Agricultural and Veterinary Sciences
Medical and Health Sciences