Antimalarial activity of sera from subjects taking HIV protease inhibitors
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Redmond, Andrew M
Skinner-Adams, Tina
Andrews, Katherine T
Gardiner, Donald L
Ray, John
Kelly, Mark
McCarthy, James S
Skinner-Adams, Tina
Andrews, Katherine T
Gardiner, Donald L
Ray, John
Kelly, Mark
McCarthy, James S
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Date
2007
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Abstract
Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.
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AIDS
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21
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6
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Subject
Biological sciences
Biomedical and clinical sciences
Psychology
Health sciences