Antimalarial activity of sera from subjects taking HIV protease inhibitors

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Redmond, Andrew M
Skinner-Adams, Tina
Andrews, Katherine T
Gardiner, Donald L
Ray, John
Kelly, Mark
McCarthy, James S
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2007
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Abstract

Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.

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AIDS

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21

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6

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Biological sciences

Biomedical and clinical sciences

Psychology

Health sciences

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