A Narrative Review of the Evidence for Transcatheter Aortic Valve Implants

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Lee, Leonard
Chan, Brendan Min-Wei
Spencer, Melinda
Leung, Jovi
Liew, Danny
Kim, Hansoo
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2025
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Abstract

Currently, multiple transcatheter aortic valves exist in clinical use, with varying efficacy and safety rates. This review aims to evaluate the evidence base for current transcatheter valves used in the management of aortic stenosis in Australia to improve informed decision making for both clinicians and patients. The evidence base included published peer-reviewed human studies of aortic valves with approval for use in Australia through the Therapeutic Goods Administration (TGA). Embase was utilised on the 17 September 2024, and one hundred ninety-seven publications met the inclusion criteria, including six from citation searching. The Sapien series led with the largest number of patients reported in the literature (n = 91,614) and publications (n = 147), followed by the CoreValve/Evolut series with 65,459 patients and 125 publications. Evidence for both of these transcatheter aortic valve series were also published in high impact journals, with the greatest H-index journal being The New England Journal of Medicine. In conclusion, the evidence base for the safety and efficacy of the Sapien and CoreValve/Evolut series currently leads in both quantity and quality. This review also summarises the Australian medical device regulatory and funding process in the context of transcatheter aortic valves.

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Journal of Cardiovascular Development and Disease

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12

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4

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Lee, L; Chan, BM-W; Spencer, M; Leung, J; Liew, D; Kim, H, A Narrative Review of the Evidence for Transcatheter Aortic Valve Implants, Journal of Cardiovascular Development and Disease, 12 (4), pp. 113

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