WAO - ARIA consensus on chronic cough: Executive summary

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Rouadi, Philip W
Idriss, Samar A
Bousquet, Jean
Morais-Almeida, Mario
Azar, Cecilio R
Al-Ahmad, Mona Sulaiman
Yanez, Anahi
Al-Nesf, Maryam Ali Y
Nsouli, Talal M
Bahna, Sami L
Abou-Jaoude, Eliane
Zaitoun, Fares H
Hadi, Usamah M
Scadding, Glenis K
Smith, Peter K
et al.
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2025
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Abstract

Acute cough is a highly prevalent symptom in clinical practice. Chronic cough is a complex disease with significant impact on quality of life. The mechanistic pathways of chronic cough in cough-comorbid clinical phenotypes are elusive. Mounting evidence suggests presence of a hypersensitive cough reflex and implication of transient receptor potential channels and P2X receptors in cough neuronal pathways. Previously, the World Allergy Organization (WAO)/Allergic Rhinitis and its Impact on Asthma (ARIA) Joint Committee on Chronic Cough published updated experimental and clinical data on chronic cough, in addition to a multidisciplinary care pathway approach to its management. The goal of this manuscript is to provide clinicians with a succinct summary of chronic cough pathophysiology, clinical phenotypes, and management strategies in both primary and cough specialty care. This executive summary is a primer for clinicians on chronic cough. Increasing awareness on the topic among primary care physicians will improve the outcome of management of patients with chronic cough.

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World Allergy Organization Journal

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18

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3

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© 2025 The Authors. Published by Elsevier Inc. on behalf of World Allergy Organization. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Rouadi, PW; Idriss, SA; Bousquet, J; Morais-Almeida, M; Azar, CR; Al-Ahmad, MS; Yanez, A; Al-Nesf, MAY; Nsouli, TM; Bahna, SL; Abou-Jaoude, E; Zaitoun, FH; Hadi, UM; Scadding, GK; Smith, PK; et al., WAO- ARIA consensus on chronic cough Executive summary, World Allergy Organization Journal, 2025, 18 (3), pp. 101034

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