A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation
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Krasavin, Mikhail
V. Sapegin, Alexander
V. Dorogov, Mikhail
V. Sapegin, Alexander
V. Dorogov, Mikhail
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2015
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Abstract
We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
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Tetrahedron Letters
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56
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1
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Chemical Sciences not elsewhere classified
Medicinal and Biomolecular Chemistry
Organic Chemistry