Background Greater research utilisation in cancer nursing practice is needed in Australia in order to provide well-informed and effective nursing care to people affected by cancer. This paper reports the implementation of evidence-based practice in a tertiary cancer care centre. Methods Using a case report design, this paper reports on the use of the Collaborative Model for Evidence-Based Practice in an Australian tertiary cancer care centre. The clinical case describes the uptake of routine application of chlorhexidine-impregnated sponge dressings for preventing centrally inserted catheter-related bloodstream infections - a common problem in people with cancer. The processes that resulted in a service-wide practice change are described. Results This model was considered a feasible method for successful research utilisation. In this case report, the chlorhexidineimpregnated sponge dressings were introduced in the tertiary cancer care centre with the aim of reducing the incidence of centrally inserted catheter-related bloodstream infections and potentially improving patient health outcomes. Conclusion The collaborative model is feasible and effective for implementing clinical evidence into cancer nursing practice. The successful implementation of evidence-based practice in cancer care centres requires cancer nurses and health administrators to ensure a supportive infrastructure and environment for clinical inquiry and research utilisation.