Objective: To prospectively explore predictors of hope in people with colorectal cancer at 24 months post‐diagnosis.

Methods: The present study is a secondary analysis of two waves within a longitudinal survey of patients newly diagnosed with colorectal cancer in Queensland, Australia. Baseline predictors (sociodemographic, disease, lifestyle characteristics, cancer threat appraisal and quality of life domains) were measured via mailed surveys and telephone interviews at 6 months post‐diagnosis. Hope was measured via mailed surveys at 24 months post‐diagnosis.

Results: At 24 months post‐diagnosis, 1,265 participants completed the hope measure. Hope was predicted by higher education, physical activity, cancer threat appraisal and each quality of life domain (i.e., physical, social, emotional and functional well‐being; and colorectal cancer‐specific concerns), which explained 23.63% of the total variance in hope, F(14, 1,081) = 23.89, p < 0.001.

Conclusion: At 24 months post‐diagnosis, hope was associated with greater functional, social and emotional well‐being, and less threatened cancer appraisals. As hope programmes continue to be developed, designers should include activities that increase well‐being and reduce cancer threat appraisal for people with colorectal cancer.