Exacerbation of Alphaviral Arthritis and Myositis in a Mouse Model after Etanercept Treatment is due to Diminished Levels of Interferon α/β

Loading...
Thumbnail Image
File version

Version of Record (VoR)

Author(s)
Zaid, Ali
Sheng, Kuo-Ching
Taylor, Adam
Rulli, Nestor
Herrero, Lara
McNeil, Patrick
Mahalingam, Suresh
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2013
Size
File type(s)
Location
Abstract

Little is known about the possible use of TNF-α inhibitors for treating viral arthritis and myositis caused by mosquitoborne arthritogenic alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), and Barmah Forest virus. Emerging alphaviruses such as CHIKV, Mayaro virus and O’nyong-nyong virus are now considered significant public health threats by the World Health Organisation (WHO), with reports of severe cases of debilitating arthritis and arthralgia due to these agents in numerous regions of the world [1]. Although alphavirus-induced arthritis is generally self-limiting, the disease can be severe and the virus can persist and establish chronic infection [1]. For example, Hourau et al. recently showed the persistence of CHIKV antigen in perivascular synovial macrophages in a patient 18 months after infection [2]. At present, there are no alphavirus vaccines or antiviral drugs available for humans. The current treatments available for symptoms caused by alphavirus disease consist of non-steroidal anti-inflammatory drugs such as aspirin or ibuprofen.

Journal Title

Virology & Mycology

Conference Title
Book Title
Edition
Volume

2

Issue

3

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2013 Zaid A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Access Status
Note
Access the data
Related item(s)
Subject

Medical virology

Persistent link to this record
Citation

Zaid, A; Sheng, K-C; Taylor, A; Rulli, N; Herrero, L; McNeil, P; Mahalingam, S, Exacerbation of Alphaviral Arthritis and Myositis in a Mouse Model after Etanercept Treatment is due to Diminished Levels of Interferon α/β, Virology & Mycology, 2013, 2 (3), pp. 1000122

Collections