Nurses are at high risk for work-related injury. This paper examines key determinants of such injury among a sample of nurses in Queensland, Australia. Data were based on the Work Outcomes Research Cost-Benefit Survey conducted in Australia during 2005 and 2006. The study sample of 5724 represented ~14% of nurses in Queensland at the time. Logistic regression was used to determine the magnitude of association of psychological distress, the number of health conditions and various socio-economic factors with work place injury. High psychological distress was associated with a 5% probability of injury. As the number of health conditions increased, the probability of injury increased. Compared to the total sample, nurses that reported high levels of psychological distress demonstrated greater sensitivity to the number of health conditions. Little difference was found in the likelihood of injury when the total sample was compared to nurses with less than 5 years of work experience.