High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma

Loading...
Thumbnail Image
File version
Author(s)
Green, Michael
Gandhi, Maher
Camilleri, Emily
Marlton, Paula
Lea, Rodney
Griffiths, Lyn
Primary Supervisor
Other Supervisors
Editor(s)
Date
2009
Size

161551 bytes

File type(s)

application/pdf

Location
License
Abstract

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large Bcell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.

Journal Title

Leukemia Research

Conference Title
Book Title
Edition
Volume

33

Issue
Thesis Type
Degree Program
School
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

Item Access Status
Note
Access the data
Related item(s)
Subject

Clinical Sciences

Persistent link to this record
Citation
Collections