Oral Microbiota and their Volatile Metabolites in Oral Squamous Cell Carcinoma
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Wei, Ming
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Zhang, Li
Nair, Raj
Samaranayake, Lakshman Perera
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Abstract
The majority of the oral neoplasms are oral squamous cell carcinoma (OSCC) which have been traditionally linked to consumption of tobacco and alcohol. The human papillomavirus (HPV) infection is also significantly associated with OSCC progression. However, the prevalence of this cancer in people with no record of those traditional factors emphasized the possibility of another significant factor that potentially contributes to OSCC. Bacteria have been strongly associated with some cancers especially in gastric cancer. Several microbial metabolites are categorised as carcinogens that suggest the direct and indirect role of microbes in cancer development. The new insight into human microbiome using high- throughput technologies revealed the variation in the human microbiota between healthy adults and cancer patients that have not been achieved using low- throughput methods. The oral microbiota analysis in OSCC using high- throughput technologies limited to the analysis of the bacteria associated with the cancerous site and the analysis of OSCC’s intraoral microbiota is understudied. The human microbe-metabolite association with cancer was obtained previously, and the results indicated a potential use of human sample metabolites for the differentiation between healthy adults and cancer patients. However, the method employed in those studies was not ideal for the analysis of microbial metabolites independently from human metabolome. This is because that the accuracy and reproducibility of direct human sample metabolomics undergo variations with both human and microbial samples.
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Thesis (PhD Doctorate)
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Doctor of Philosophy (PhD)
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School of Medical Science
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The author owns the copyright in this thesis, unless stated otherwise.
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Subject
Oral squamous cell carcinoma
Oral neoplasms
Human papillomavirus (HPV) infection
Oral microbiota
Volatile metabolites