The use of thrombolysis in specified patient presentations is supported in the acute phase following ischaemic stroke by stroke clinical guidelines. However, thrombolysis is associated with a number of complications and risks. Further, thrombolysis protocol violations have been associated with increased patient mortality. Although the risks associated with thrombolysis and non-compliance with protocols are recognised, a review of literature and benchmarking suggested that no specific protocols existed to guide speech pathologists through dysphagia management during the critical time period directly postthrombolysis. As a result, Logan Hospital Speech Pathology Department sought to develop an evidence-based clinical practice protocol to standardise dysphagia service delivery and limit patient and staff risk. This paper presents a review of literature in this area and details regarding the development of The Logan Hospital Dysphagia Clinical Protocol for Thrombolysed Patients.